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Inhibitors Cimetidine Cimetidine inhibits the hepatic metabolism of diazepam, lowering its clearance and prolonging its 50 percent-lifetime. In a single stude where by three hundred mg cimetidine was administered 4 situations daily for two months, the put together plasma volume of diazepam and its Lively metabolite, desmethyldiazepam,was uncovered

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